MODULATING BLOOD PROFILES: THE PROTECTIVE ROLE OF CUCUMEROPSIS MANNII SEED OIL IN ALBINO RATS EXPOSED TO CISPLATIN TOXICITY

Abstract

This research work was designed to determine the modulatory effect of Cucumeropsis mannii seed oil (CMSO) on hematological parameters of cisplatin induced toxicity in albino rats. A total of 36 albino rats were randomly assigned into six experimental groups. Group1 (normal control) was fed on pellet and allowed free access to water; Group2 (cisplatin only) received 20mg/Kg body weight of cisplatin only; Group3 (treated group) received 20mg/Kg body weight of cisplatin and 5ml/Kg b.w. of CMSO; Group4 (treated group) received 20mg/Kg body weight of cisplatin and 2.5 ml/Kg b.w. of CMSO; Group5 (treated group) received 20mg/Kg body weight of cisplatin and 7.5ml/Kg b.w. of CMSO; Group6 (CMSO only) received 5ml/Kg body weight of CMSO only. All the animals were allowed free access to water and feed without restriction. The administrations were done by oral intubation once daily for three weeks. The results showed that administration of cisplatin to albino rats caused a significant (p<0.05) decrease in the levels of red blood cell count and significantly (p<0.05) increase in the level of white blood cell count when compared to controls. The results also showed that administration of cisplatin to albino rats showed a significant (p<0.05) decrease in the levels of hemoglobin and PCV in relation to controls. However, concurrent administration of cisplatin and CMSO showed a significant (p<0.05) reversal in the trends of these parameters to a level comparable to the level observed in the control group when compared to group that received cisplatin alone. The result also revealed that there was no significant (p>0.05) difference in the group administered CMSO only when compared with the normal controls. It’s recommended that Cucumeropsis mannii seed oil could be used to manage hematological imbalance in cisplatin administrations.